This handout is designed to complement the course Opioid Use Disorder in Primary Care: Principles of Assessment and Management in the Opioids Clinical Primer CPD Series and includes an overview of opioid use disorder diagnostic criteria and assessment principles; opioid withdrawal symptoms; what to do if you recognize that a patient has an opioid use disorder; options for the treatment of opioid use disorder; and some additional links to supports and key resources. Updated November 10, 2022